Verapamil Injections for Peyronie’s Disease
What This Treatment Is For
Intralesional verapamil is a non-surgical treatment for Peyronie’s disease designed to reduce penile plaque and improve curvature. It works by decreasing collagen buildup and improving tissue elasticity. Verapamil injections are often used as an alternative to collagenase clostridium histolyticum (Xiaflex) for men who prefer a cost-effective, evidence-based therapy.
Who It’s For
This treatment is recommended for men with early (acute) Peyronie’s disease who experience painful erections and evolving curvature, as well as men in the stable (chronic) phase with persistent plaques. It is best suited for those with mild to moderate curvature who wish to avoid surgery or are not eligible for Xiaflex.
How the Procedure Works
Treatments are performed in-office. A small amount of verapamil is injected directly into the penile plaque using a fine needle. A topical or local anesthetic is used to minimize discomfort. Sessions are typically performed once weekly or every two weeks, with a course of 6–12 injections depending on response.
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Expected Results
Results vary, but many patients experience reduced penile pain, partial straightening, and softening of plaques, improving sexual function over time. Best results occur when combined with traction therapy.
Risks & Safety
Side effects may include temporary bruising, swelling, or discomfort at the injection site. Rare risks include small hematoma or erectile dysfunction.
Results & Follow-Up
Other treatment options include Xiaflex injections, penile traction therapy, or surgery (plication, grafting, or penile implant for severe cases).
frequently asked questions
Get answers to common questions about urology and men’s health
How many injections will I need?
Most men need 6–12 sessions for best results.
Is it covered by insurance?
Coverage varies; our team will verify your benefits.